Sleep loss linked to Alzheimer’s disease


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A new study shows that even a single bad night sleep could raise levels of a protein that causes clogs in the brain and result in dementia.

The study, conducted by researchers at the University of Washington and Stanford University, sampled 17 healthy adults between the ages of 35 and 65 with no known sleep or cognitive problems. It was published in the journal Brain.
The results show that amyloid levels increase by about 10 percent and tau levels would increase if the slow-wave sleep interruption continues for some nights in a row.
Amyloid beta and tau are two naturally occurring proteins, but can cause clogs and tangles in the brain. Proteins are eliminated when the body goes into slow-wave sleep.
Amyloid beta protein in excess of 10 percent could cause amyloid plaques that lead to dementia. Increasing tau could cause brain entanglements that lead to Alzheimer's disease.

"When people are in a pleasant and deep sleep, they get a period of time when, with normal cleaning mechanisms in place, amyloid levels decrease. If levels increase over the years, they are more likely to cause Lumps called plaques, that do not dissolve, "said Dr. Yo-El Ju of the University of Washington in St. Louis and lead study on NBC News.

More than 5 million Americans have Alzheimer's disease and many more are expected to develop the disease as the population ages. There is no cure or treatment for the disease.

RUNDOWN SHOWS:
1. Amyloid and tau produced in the brain
2. Slow wave sleep erases the accumulation of proteins
3. Slow wave sleep interruption leads to rapid accumulation of proteins
4. Amyloid plaque and tau entanglement in the brain

VOICEOVER (in English):
"Amyloid beta and tau are two proteins in the brain that occur naturally but can cause clogs and tangles in the brain."

"Proteins are eliminated when the body goes into slow-wave sleep."

"Experiments have shown that amyloid levels increase by 10 percent and tau levels also increase when slow-wave sleep is disrupted for a few consecutive consecutive nights."

"Amyloid beta protein levels by more than 10 percent could cause amyloid plaques that lead to dementia. Meanwhile, increased tau may cause brain entanglements that lead to Alzheimer's disease."

SOURCES: Brain, NBC News, The Telegraph, National Institute on Aging

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Sleep loss linked to Alzheimer’s disease

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